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  • What is the optimal dosing of 4-factor prothrombin complex concentrate in patients with warfarin-associated bleeding?
  • Is there updated information on the off-label use of dexmedetomidine (Precedex®) for alcohol withdrawal syndrome?
  • What is the available evidence for the use of sodium thiosulfate for non-uremic calciphylaxis?


  • What drugs can be used to manage floppy iris syndrome during cataract surgery?
  • What is the latest information on gadolinium-based contrast agents and brain deposits?
  • Is there literature to support the adjunct use of simethicone prior to colonoscopy to improve visualization?


  • What are the data on efficacy and safety of using injectable tobramycin for inhalation via nebulization?
  • What are the comparative clinical data for albuterol versus levalbuterol?
  • What evidence supports the efficacy of ranolazine (Ranexa®) for the treatment of atrial fibrillation?


  • Dexrazoxane and the risk secondary cancer in pediatric patients: Can this controversy be laid to rest?
  • What are alternatives to sublingually administered ophthalmic atropine for treatment of noisy breathing in terminally ill patients?
  • How should medications be appropriately managed following bariatric surgery?


  • What evidence supports the use of antibiotic-loaded bone cement to prevent infection in primary hip and knee arthroplasty?
  • What does the American Psychiatric Association recommend regarding the use of antipsychotics in patients with dementia?
  • Can a simplified 2-bag acetylcysteine approach improve tolerability in acetaminophen overdoses?


  • What evidence is available for the use of fluorescein for gastrointestinal and genitourinary procedures?
  • What is the evidence to support the new 2016 heart failure update and place in therapy of the new heart failure agents?
  • What is the comparative evidence on use of IV acetaminophen versus oral acetaminophen?


  • What evidence is available for efficacy and stability of high dose mitomycin C concentrations?
  • What evidence supports or refutes the use of medical grade honey for wound healing?
  • What are the new 2016 ACC/AHA guideline recommendations for dual antiplatelet therapy?


  • What are the key changes to drug therapy recommendations in the 2016 AACE type 2 diabetes algorithm?
  • What are the clinical implications of the 2016 American Epilepsy Society (AES) guidelines for status epilepticus?
  • What is the clinical evidence for the use of sugammadex (Bridion®)?


  • What are the 2016 guideline recommendations for the management of postoperative pain?
  • What is the most recent evidence for using probiotics in patients with Clostridium difficile?
  • Does adjunctive corticosteroid therapy improve outcomes in patients with community-acquired pneumonia?


  • What data support selexipag and initial ambrisentan/tadalafil therapy for pulmonary arterial hypertension?
  • What information is available on Zika virus infection?
  • What are the major drug-related changes to the 2016 update of the CHEST Guideline for Antithrombotic Therapy for VTE Disease?


  • Do the insulin glargine products Basaglar and Lantus have similar safety and efficacy profiles?
  • Should blood pressure goals be lowered based on recent evidence?
  • Are proton pump inhibitors (PPIs) associated with negative outcomes in patients with cirrhosis?


  • What data are available comparing liposomal bupivacaine to other agents?
  • Can estimated patient weight be safely used for dosing of alteplase for acute ischemic stroke?
  • What are the key features of the new rheumatoid arthritis guidelines?