2012

December

  • What alternatives to codeine are available for post-tonsillectomy and post-adenoidectomy analgesia?
  • How do the 2 factor VIII concentrations, Xyntha and Advate, differ?
  • What is the most recent information on West Nile Virus?

November

  • Does extended infusion piperacillin-tazobactam (Zosyn) improve clinical outcomes?
  • What are the most recent antimicrobial prophylaxis guidelines from the Medical Letter?
  • What is the efficacy of rectal NSAIDs for prevention of pancreatitis post-ERCP?

October

  • What literature supports using a “common canister” protocol to avoid wasting unused drug from partially used multiple dose inhalers in hospitalized patients?
  • Is dexmedetomidine safe and appropriate for sedation of critically ill children with heart disease?
  • What is hantavirus disease and what are the options for prevention and treatment?

September

  • Do selective serotonin reuptake inhibitors increase the risk of upper gastrointestinal bleeds?
  • What are the data supporting the approval of the new, purified omega-3 lipid agent (icosapent ethyl)?
  • What are the recommendations for use of the meningococcal vaccines Menomune, Menactra, and Menveo?

August

  • What is the place in therapy for 13-valent pneumococcal conjugate vaccine (PCV13) for prevention of pneumococcal infection in adults?
  • Are proton pump inhibitors more effective than histamine-2 receptor antagonists for stress ulcer prophylaxis?
  • What are the new recommendations for dosing chemotherapy in obese patients?

July

  • Does azithromycin increase the risk of cardiovascular death?
  • What are the most recent guidelines for the treatment of diabetic foot infections?
  • What information is available on intravenous acetaminophen overdose in children?

June

  • How should Helicobacter pylori infection be treated in the context of increasing resistance to antibiotics and current shortages of clarithromycin and tetracycline?
  • What do the new guidelines for use of intravenous immunoglobulin (IVIG) in the treatment of neuromuscular disorders recommend?
  • What medications are included in the most recent Beer’s criteria?

May

  • Does metformin decrease the risk of breast cancer?
  • Is dexmedetomidine an appropriate agent for long-term sedation in mechanically ventilated ICU patients?
  • What is the Adverse Event Reporting System (AERS)?

April

  • What are the current recommendations from the American College of Chest Physicians for thromboembolism prophylaxis in orthopedic surgery patients?
  • Which drugs have been associated with causing thrombocytopenia?
  • What are the new drug interaction dosing recommendations for statins?

March

  • Do statins increase the risk of developing diabetes?
  • What is glucarpidase and what is its role in treatment of methotrexate toxicity?
  • What are the post-marketing safety concerns with dabigatran?

Feburary

  • Do Stimulant Medications for Attention Deficit/Hyperactivity Disorder Cause an Increase in Cardiovascular Sudden Death?
  • What are the new recommendations for management of acute uncomplicated cystitis and pyelonephritis in women?
  • What is the efficacy of atypical antipsychotics for off-label uses?

January

  • Can the interval between INRs be extended in patients receiving stable doses of warfarin?
  • What is the recommended preoperative use of epoetin for blood conservation?
  • What are the medication guide distribution requirements as part of REMS?