2011

December

  • How can late vitamin K deficiency bleeding (VKDB) in infants be prevented when the 1 mg/0.5 mL vitamin K parenteral preparation is on shortage?
  • What are the differences between the new oral anticoagulants?
  • Is a vancomycin dosing nomogram effective for achieving a trough concentration of 15-20 mg/L in adult patients?

November

  • Updated guidelines for chronic obstructive lung disease: what are the current recommendations?
  • Fluzone Intradermal-what is its place in therapy?
  • What is the role of telaprevir and boceprevir in the treatment of chronic hepatitic C infection?

October

  • When should parenteral nutrition be initiated in critically ill patients?
  • What methods are available for reversal of dabigatran and rivaroxaban?
  • Is there a difference between the nitroglycerin sublingual tablet and spray formulations for the treatment of angina?

September

  • What is the place in therapy of linagliptin for type 2 diabetes?
  • What is rilpivirine?
  • Does varenicline (Chantix) increase the risk of cardiovascular events in patients with cardiovascular disease?

August

  • What is Rivaroxaban's (Xarelto) place in therapy?
  • Magnesium Sulfate Shortage-Are there effective and safe alternatives for the treatment of preeclampsia?
  • What are alternatives to N-acetylcysteine as a mucolytic?

July

  • What are the new recommendations for managing hypertension in the elderly?
  • Why was the niacin AIM-HIGH trial stopped early?
  • What are the new recommendations for pharmacological interventions used to conserve blood in cardiovascular procedures?

June

  • What are the new American Society of Clinical Oncology Guidelines on the Role of Bone-Modifying Agents in Metastatic Cancer?
  • What are the new recommendations for treatment of painful diabetic neuropathy?
  • Can early initiation of antiretroviral therapy protect uninfected sexual partners from HIV infection?
  • What are the new recommendations from the Infectious Diseases Society of America (IDSA) for the use of antimicrobial agents in neutropenic patients with cancer?

May

  • Is Fidaxomicin an Effective Future Treatment for Clostridium difficile Infection?
  • What is the Efficacy of Intravenous Levetiracetam for Acute Seizure Management in Adults and Children?
  • What are the Latest Guidelines for Prevention of Intravascular Catheter-related Infections?
  • What are the Efficacy and Safety Data Supporting the Use of Roflumilast in the Treatment of COPD?

April

  • What are the new recommendations from the American Thoracic Society on the treatment of pulmonary fungal infections in critically ill patients?
  • What are the new recommendations from the Infectious Diseases Society of American for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)?
  • What are the current recommendations for tocolysis?
  • What are the new safety warnings for topiramate in pregnant women?

March

  • What is hydroxyprogesterone caproate?
  • What literature is available describing the interaction between macrolides and calcium-channel blockers (CCBs)?
  • How is drug absorption altered by bariatric surgery?
  • Is there a role for topical tranexamic acid to prevent postsurgical bleeding from major cardiovascular and orthopedic procedures?

Feburary

  • What drugs are likely to interfere with urine drug screens?
  • Are calcium and magnesium infusions effective for prevention of oxaliplatin-related neurotoxicity?
  • Should Truvada (emtricitabine/tenofovir) be given for preexposure prophylaxis against HIV?
  • What are the new recommendations in the 2011 Focused Update to the ACCF/AHA atrial fibrillation guidelines?

January

  • Is the brand vs generic antibiotic controversy valid?
  • Is Dabigatran the Next Warfarin?
  • What is the efficacy and safety data supporting the approval of tesamorelin for treatment of HIV patients with lipodystrophy?
  • Why has the FDA removed the breast cancer indication for Avastin?